What do you think?
I'm still getting used to the art style and the changes. It's getting easier as I keep playing.
I've done 5 runs and on beat Mom's Heart on the last one, unlocked Lazarus, Azazel and Eden. Haven't used the last two yet as I just unlocked them.
Best item combo I got so far was the Inner Eye, two Range Up Pills and some item that gives Mega Tears (didn't catch the name) - could easily 2 or 3 shot most bosses. Another run I got Technology plus Infestation Shot, which was kind of OP as well.
On my last run I got something interesting (spoilered because I haven't seen it mentioned anywhere yet):
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